Year : 2020 | Volume
: 31 | Issue : 3 | Page : 123--130
Smoking behavior and survival outcomes in bladder cancer patients
Wei-Chung Chu, Chung-Hsin Chen
Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Purpose: The purpose of this study was to compare the survival outcomes of bladder cancer patients with different smoking behaviors.
Materials and Methods: Between January 2011 and December 2014, a total of 565 bladder cancer patients were included from one institute retrospectively. Regarding smoking behavior, among these patients, 337 were nonsmokers, 52 were “quitters” (patients who had quit smoking ≥10 years ago), 54 were ex-smokers (patients who had quit smoking <10 years ago), and 117 were current smokers. We compared the clinicopathological characteristics and survival outcomes among these four groups.
Results: In this cohort, the 3-year overall survival (OS) (95% confidence interval [CI]) of the nonsmoker, quitter, ex-smoker, and current smoker groups were 75.6% (95% CI: 72.9%–78.3%), 67.4% (95% CI: 59.8%–75%), 84.1% (95% CI: 78.9%–89.3%), and 83.2% (95% CI: 79.3%–87.1%), respectively. Nonsmoker patients included a higher number of females, and quitters were older than the patients in the other groups. Larger tumors in quitters and higher clinical stages in ex-smokers were observed more frequently than in the patients of the other groups. Compared with nonsmokers, quitters, and ex-smokers, current smokers had no impact on OS (P = 0.541, 0.406, and 0.175, respectively) nor on cancer-specific survival (CSS) (P = 0.631, 0.388, and 0.193, respectively). Higher diagnostic age, being underweight, larger tumor sizes, and higher clinical stages were independent factors predicting OS.
Conclusion: Smoking behavior seemed to not directly contribute to the deterioration of overall or CSS duration in patients with bladder cancer.
Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei; No.1, Changde St., Zhongzheng Dist., Taipei City 10048
|How to cite this article:|
Chu WC, Chen CH. Smoking behavior and survival outcomes in bladder cancer patients.Urol Sci 2020;31:123-130
|How to cite this URL:|
Chu WC, Chen CH. Smoking behavior and survival outcomes in bladder cancer patients. Urol Sci [serial online] 2020 [cited 2021 May 12 ];31:123-130
Available from: https://www.e-urol-sci.com/article.asp?issn=1879-5226;year=2020;volume=31;issue=3;spage=123;epage=130;aulast=Chu;type=0