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Year : 2020  |  Volume : 31  |  Issue : 5  |  Page : 216-220

Comparison of prophylactic antibiotics in patients without pyuria undergoing ureterorenoscopic surgery

Department of Urology, National Taiwan University Hospital, Taipei, Taiwan

Correspondence Address:
Yuan-Ju Lee
Department of Urology, National Taiwan University Hospital, Taipei
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/UROS.UROS_40_20

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Purpose: The objective of this study was to evaluate the efficacy of antibiotic prophylaxis in patients with a tentative diagnosis of ureteral stones undergoing ureterorenoscopic surgery. Materials and Methods: This is a single-surgeon, open-label randomized controlled trial, which enrolled 109 patients from May 2014 to September 2018. The patients were equally randomized into three groups: a group with a single dose of intravenous cefazolin (1g), a group with oral cefuroxime (500 mg), and a control group with no prophylactic antibiotics. The primary end points were the rate of febrile urinary tract infections (UTIs) and postoperative pyuria. Results: The rate of postoperative fever was 9.4% in the cefazolin group (3 in 32), 0% in the cefuroxime group (0 in 29), and 6.9% in the control group (2 in 36). There was no statistically significant difference between the cefazolin and control groups (P = 0.1). The rate of postoperative pyuria was 64.3% in the cefazolin group, 58.3% in the cefuroxime group, and 33.3% in the control group, without statistically significant differences between the groups. Conclusion: Antibiotic prophylaxis could not reduce the incidence of postoperative febrile UTI and pyuria in ureterorenoscopic lithotripsy.

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