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Year : 2018  |  Volume : 29  |  Issue : 5  |  Page : 231-236

The risk of venous thromboembolism in patients with lower urinary tract symptoms

1 Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi, Taiwan
2 Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi; Chang Gung University of Science and Technology, Chia-Yi, Taiwan; Department of Medicine, Chang Gung University, Taoyuan, Taiwan
3 Management Office for Health Data, China Medical University Hospital; School of Medicine, China Medical University, Taichung, Taiwan
4 Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University; Department of Nuclear Medicine and PET Center, China Medical University Hospital; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan

Correspondence Address:
Wei-Yu Lin
Department of Surgery, Division of Urology, Chang Gung Memorial Hospital, Chia-Yi 61363
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/UROS.UROS_33_18

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Objectives: Atherosclerosis may lead to chronic bladder ischemia, which eventually results in lower urinary tract symptoms (LUTS). Patients with venous thromboembolism (VTE) have a higher prevalence of atherosclerosis. Methods: A total of 31,559 patients had been diagnosed with or without LUTS between 2000 and 2010 in Taiwan National Health Insurance Research Database, each was enrolled in the LUTS and non-LUTS cohorts, respectively. The risk of VTE in LUTS and non-LUTS cohorts was calculated by Cox proportional hazards regression model. Results: After adjustment for age, sex, and comorbidities, the risk of subsequent VTE was 1.34-fold higher in the LUTS than in the non-LUTS cohort. The adjusted risk of VTE was highest in patients with LUTS with any comorbidity. The age-specific relative risk of VTE was significantly higher in patients aged ≥50 years, particularly in those aged 50–64 years, in the LUTS than in the non-LUTS cohort. Conclusions: LUTS is a risk factor for VTE. Physicians should consider the possibility of underlying VTE in patients aged ≥50 years having cardiovascular comorbidities.

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