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  Indian J Med Microbiol
 

Figure 1: Schematic representation of the autophagy process and core autophagy protein complexes. The autophagy is a multi-step process, including induction of phagophore formation, elongation, autophagosome maturation (formation), lysosome fusion, and degradation. Following the initiation signaling or genotoxic stresses which resulted in mammalian target of rapamycin inhibition the autophagic vesicles are formed from the isolation membrane to the autophagosome and autophagolysosome (autolysosome). ULK1/2 complex that downstream of mammalian target of rapamycin mediated the early process followed by class III PI3K complex. Subsequently, LC3 processing and the nascent complex further facilitate the elongation and expansion of the phagophore to form a double membrane autophagosome. The autolysosome is formed through the fusion with lysosomes where cargo is degraded to generate amino and fatty acids for energy generation

Figure 1: Schematic representation of the autophagy process and core autophagy protein complexes. The autophagy is a multi-step process, including induction of phagophore formation, elongation, autophagosome maturation (formation), lysosome fusion, and degradation. Following the initiation signaling or genotoxic stresses which resulted in mammalian target of rapamycin inhibition the autophagic vesicles are formed from the isolation membrane to the autophagosome and autophagolysosome (autolysosome). ULK1/2 complex that downstream of mammalian target of rapamycin mediated the early process followed by class III PI3K complex. Subsequently, LC3 processing and the nascent complex further facilitate the elongation and expansion of the phagophore to form a double membrane autophagosome. The autolysosome is formed through the fusion with lysosomes where cargo is degraded to generate amino and fatty acids for energy generation