|Year : 2020 | Volume
| Issue : 1 | Page : 21-27
Comparative analysis of robot-assisted, laparoscopic, and open radical prostatectomy regarding lower urinary tract symptoms: A longitudinal study
Shogo Inoue, Tetsutaro Hayashi, Jun Teishima, Akio Matsubara
Department of Urology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
|Date of Submission||28-Jun-2019|
|Date of Decision||01-Sep-2019|
|Date of Acceptance||26-Sep-2019|
|Date of Web Publication||20-Feb-2020|
Dr. Shogo Inoue
Department of Urology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551
Source of Support: None, Conflict of Interest: None
Purpose: This study aims to assess lower urinary tract symptoms (LUTS) after radical prostatectomy (RP) and compare longitudinally the short-time LUTS changes of three techniques: robot-assisted RP (RARP), laparoscopic RP (LRP), and open RP (ORP). Materials and Methods: We reviewed prospectively the collected longitudinal data on the International Prostate Symptom Score (IPSS) from patients who performed RP for localized prostate cancer. One-year longitudinal data (preoperatively and at postoperative 3, 6, and 12 months) on IPSS were available for 322 patients. The number of patients was 231 for RARP, 42 for LRP, and 49 for ORP. LUTS was assessed on the basis of the IPSS and the IPSS quality of life (QOL) score. Results: The IPSS and IPSS related QOL scores were significantly improved over the baseline score not for the LRP and ORP but for the RARP. For patients with moderate to severe LUTS preoperatively, the RARP group immediately improved in terms of preoperative LUTS differently from both LRP and ORP groups. Only RARP significantly improved in terms of voiding symptom composites (VSC) differently from both LRP and ORP procedures. However, none of the procedures changed in terms of storage symptom composites (SSC) longitudinally. Conclusions: The improvement of LUTS for RARP may contribute to the improvement of not only SSC but also VSC.
Keywords: Longitudinal study, lower urinary tract symptoms, quality of life, radical prostatectomy
|How to cite this article:|
Inoue S, Hayashi T, Teishima J, Matsubara A. Comparative analysis of robot-assisted, laparoscopic, and open radical prostatectomy regarding lower urinary tract symptoms: A longitudinal study. Urol Sci 2020;31:21-7
|How to cite this URL:|
Inoue S, Hayashi T, Teishima J, Matsubara A. Comparative analysis of robot-assisted, laparoscopic, and open radical prostatectomy regarding lower urinary tract symptoms: A longitudinal study. Urol Sci [serial online] 2020 [cited 2020 Apr 2];31:21-7. Available from: http://www.e-urol-sci.com/text.asp?2020/31/1/21/278874
| Introduction|| |
Prostate cancer (PCa) is a major cause of the increased cancer-related mortality worldwide and the second most commonly diagnosed cancer among men. Localized PCa is a good indication for radical prostatectomy (RP), radiation therapy, or active surveillance. Many of them with organ-confined PCa and a longer life expectancy prefer RP. The gold standard for RP was open RP (ORP)., Minimally invasive surgery of PCa has been increasingly performed. The evolution from pure laparoscopic RP (LRP) to robot-assisted RP (RARP) may be assigned to the steeper learning curve and technical considerations associated with LRP. Advantages of RARP include three-dimensional viewing, improved ergonomics, elimination of physiologic hand tremor, and refined dexterity.,
To date, the assessment of urinary symptoms after RP has focused primarily on urinary incontinence. However, there is little study on the impact of RP on lower urinary tract symptoms (LUTS). Although it is well known that irritative voiding symptoms are common in patients with PCa who performed RP, these symptoms significantly affect their quality of life (QOL).,,
Several studies have reported both short-term and long-term improvement in LUTS after ORP, especially in patients with severe LUTS preoperatively;,, however, there is little study comparing LUTS between various procedures of RP. This improvement in LUTS is likely because of immediate and definitive ease of bladder outlet obstruction (BOO) from the removal of the prostate gland. The impact of the improvement in LUTS is generally underestimated because of postoperative emergence of urinary incontinence.
Nevertheless, during RP, dissection of the trigone, posterior urethra at the bladder neck, and posterolateral neurovascular bundle cause dysfunctions to the lower urinary tract induced by ischemic changes and denervation. Besides, RP causes anatomic changes to the lower urinary tract, induced by removal of the prostate and subsequent reanastomosis of the urethra and bladder neck. The surgical procedure of RP transiently injuries the bladder and urethra, leading to temporarily lower urinary tract dysfunction in the early stage after surgery. Therefore, almost all patients temporarily experience not only storage but also voiding symptoms after RP.
Because the correct nature of LUTS after RP has not been proved, we investigated longitudinally the changes in LUTS, including voiding and storage symptoms, after RP by using the International Prostate Symptom Score (IPSS). Moreover, we evaluated potential factors that predict symptom changes at postoperative time points after RP. A comparative analysis on the LUTS of RARP, LRP, and ORP has yet to be conducted. The purpose of this study was to compare longitudinally the LUTS change of these three procedures.
| Subjects and Methods|| |
After we obtained approval from the Institutional Review Board (IRB) of Hiroshima University Hospital, we reviewed prospectively the collected longitudinal data on the IPSS of men who performed RP for localized PCa between September 2009 and February 2014. We excluded patients who were treated with either adjuvant or salvage radiotherapy from this investigation because of the potential impact on urinary function. We also excluded the first 20 cases in the RARP and LRP groups because we considered the influence of learning curve for both procedures. One-year longitudinal data sets (preoperatively and at 3, 6, and 12 months after RP) on IPSS were available for 322 cases. All procedures were performed by anterior approach. We also reviewed age, body mass index (BMI), serum prostate-specific antigen (PSA) at diagnosis, clinical tumor classification, biopsy Gleason score, and operative outcomes to investigate factors that may predict the changes of urinary symptoms following RP.
The study protocol was approved by the IRB of Hiroshima University Hospital (IRB No. 255). Informed consent was confirmed by the IRB.
LUTS was assessed on the basis of the IPSS and the IPSS QOL score, and both instruments were validated., The IPSS is a self-administered seven-item questionnaire comparing items of incomplete emptying, intermittency, straining, weak stream (voiding symptom composites [VSC]) and voiding frequency, nocturia, and urgency (storage symptom composites [SSC]). Each scale is scored separately from 0 to 5, with a higher score indicating a worse symptom. The IPSS is scored from 0 to 35 in all, with scores of 0–7, 8–19, and 20–35 indicating absent or mild, moderate, and severe symptoms, respectively., The IPSS QOL score is a questionnaire that quantifies the QOL for LUTS and is scored from 0 to 6, with a higher score representing a worse health state.
All patients agreed to participate in this study and signed an informed consent form. They received from their urologists a questionnaire and an envelope for returning it at preoperative baseline and at 3, 6, and 12 months postoperatively. The baseline characteristics were compared with a one-way ANOVA between RARP, LRP, and ORP. The outcome at each interval after RP was compared with the baseline level. Statistical analyses were made using the JMP version 10 statistical software package (SAS Institute Inc., Cary, NC, USA), and P < 0.05 was considered as statistically significant.
| Results|| |
A total of 322 patients were employed in our study, and the baseline characteristics of the patients for all procedures are listed in [Table 1]. The number of cases was 231 for RARP, 42 for LRP, and 49 for ORP. The mean age and serum PSA value at diagnosis were 66.3 years and 9.84 ng/ml, respectively. The median excision weight was 37.4 g. The mean operative time and estimated blood loss were 207.2 min and 286.6 ml, respectively.
There was no significant difference in age (P = 0.9637), BMI (P = 0.7268), and serum PSA at diagnosis (P = 0.1252). On the other hand, clinical tumor classification was significantly higher in the RARP group (P = 0.0084), and the biopsy Gleason score was significantly higher in the ORP group (P = 0.0408). However, there was no significant difference in worse tumor characteristics represented by higher risk stages according to the D'Amico risk classification (P = 0.2984). Operative time was significantly longer, and the estimated blood loss volume was higher in the ORP group (each P < 0.0001) [Table 2].
In only the RARP group, the overall mean total IPSS, which was 9.40 before RARP, decreased over time after 6 months from RARP and reduced significantly to 7.57 at 6 months (19% reduction, P = 0.0065) and to 6.88 at 12 months after surgery (27% reduction, P = 0.0004). The mean scores of IPSS postoperatively and at 3, 6, and 12 months were 8.22, 10.76, 8.85, and 7.64 in the LRP group and 9.88, 11.83, 10.21, and 7.53 in the ORP group, respectively. In comparison, in both the LRP and ORP groups, the overall mean total IPSS was not significantly improved compared with the score before surgery. The trend of the mean IPSS QOL score was similar to that of the overall IPSS. In only the RARP group, the mean IPSS QOL score was reduced significantly to 2.66 at 6 months (13% reduction, P = 0.0171) and to 2.44 at 12 months after surgery (20% reduction, P = 0.0005) [Figure 1].
|Figure 1: Mean total IPSS and IPSS QOL scores before and after RP. The top and bottom rows indicate the mean total IPSS and IPSS QOL scores, respectively. a and d (solid square): RARP; b and e (solid circle): LRP; c and f (solid triangles): ORP. IPSS: International Prostate Symptom Score, RP: Radical prostatectomy, RARP: Robot-assisted radical prostatectomy, LRP: Laparoscopic radical prostatectomy, and ORP: Open radical prostatectomy|
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When the data were analyzed in accordance with the symptom severity at the preoperative point, 52.6% of the patients had moderate to severe LUTS preoperatively. There were no significant differences in the portion of severe LUTS between the three techniques (P = 0.4394). For the patients with low IPSS (0–7) all patients recovered to the baseline at 12 months after surgery. In comparison, in the patients with high IPSS (8–35), the patients with LUTS who underwent LRP did not recover to the baseline level before surgery. In the RARP (14.3–9.02; 37% reduction, P = 0.0001) and ORP groups (14.1–8.96; 36% reduction, P = 0.0058), the patients with LUTS improved significantly at 12 months after surgery over the baseline levels [Figure 2].
|Figure 2: Mean total IPSS before and after radical prostatectomy stratified by the class of preoperative total IPSS. Top row: men with baseline scores of 0–7; bottom row: men with baseline scores of 8–35. a and d (solid square): RARP; b and e (solid circle): LRP; c and f (solid triangles): ORP. IPSS: International Prostate Symptom Score, RP: Radical prostatectomy, RARP: Robot-assisted radical prostatectomy, LRP: Laparoscopic radical prostatectomy, and ORP: Open radical prostatectomy|
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We evaluated the mean total IPSS before and after RP between the three techniques [Figure 3] and found that there was no significant difference between each technique. For the patients with high IPSS, the patients who underwent RARP more quickly recovered from LUTS from the baseline score than did the other two groups.
|Figure 3: Mean total IPSS before and after RP between each technique. a: overall; b: men with baseline scores of 0–7; c: men with baseline scores of 8–35; solid square: RARP; solid circle: LRP; solid triangles: ORP. IPSS: International Prostate Symptom Score, RP: Radical prostatectomy, RARP: Robot-assisted radical prostatectomy, LRP: Laparoscopic radical prostatectomy, and ORP: Open radical prostatectomy|
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We measured the IPSS for each of the seven composites including VSC and SSC before and after RP between each technique. For all composites excluding incomplete emptying in VSC only after RARP, the difference from the baseline was significant at 3 months after surgery and beyond. In the incomplete emptying score after RARP, the difference from the baseline was significant at 6 months after surgery and beyond. However, in both LRP and ORP groups, the difference from the baseline was not significant at all points after RP. For all SSC after RARP and LRP, the difference from the baseline significantly worsened only at 3 months after RP, and the SSC recovered from 6 months. However, in the only ORP group, SSC excluding urgency did not change at all points after RP [Figure 4].
|Figure 4: IPSS for each of the seven composites before and after RP between each technique. a: Incomplete emptying; b: Intermittency; c: Weak stream; d: Straining; e: Voiding frequency; f: Urgency; g: Nocturia. Top row (solid square): RARP; middle row (solid circle): LRP; bottom row (solid triangles): ORP. IPSS: International Prostate Symptom Score, RP: Radical prostatectomy, RARP: Robot-assisted radical prostatectomy, LRP: Laparoscopic radical prostatectomy, and ORP: Open radical prostatectomy|
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| Discussion|| |
In a previous study to evaluate the impact of radical perineal prostatectomy procedure on LUTS, we surveyed the change of IPSS after surgery. This present study further extended evaluation of the impact on LUTS of three techniques of RP, that is, RARP, LRP, and ORP, and clearly showed that RP induced major benefits for patients with preexisting LUTS. To date, there are no studies that have investigated longitudinal outcomes in patients with LUTS compared with various techniques of RP. It was reported that the outcomes of LUTS after ORP or RARP were short term and mixed, describing cases, especially with baseline severe LUTS.,,,
The improvement of LUTS in men with moderate to severe LUTS preoperatively would suggest that the alleviation of LUTS exceeds the decreased quality of life caused by stress incontinence after RP. Because as many as 44%–57% of patients who present for RP have moderate to severe LUTS,,, (52.6% in our study), this finding is very important when counseling patients about treatment options for clinically localized PCa. The obstruction relief by surgery attributes to the improvement of LUTS probably in most patients. It is well known that benign prostatic hypertrophy (BPH) can induce BOO and subsequently bladder overactivity and reduction of functional bladder capacity, which may worsen storage symptoms. In contrast, it has been indicated that these symptoms were improved as obstruction relief by RP in 60% of BPH cases.,
However, for patients with localized PCa, radiation therapies have been shown to incite or exacerbate LUTS immediately after treatment, and the LUTS returns to the baseline after 6–18 months for men without LUTS pretreatment., The mean decrease in American Urological Association symptom score at 12 months after ORP was reported to be 5.4 units (40% decrease) and 5.0 units (36% decrease)., In the context of RARP, there is only one study that examined LUTS longitudinally. Particularly, it was reported that men with moderate to severe LUTS improved highly (79% decrease) in terms of the mean IPSS at 12 months after RARP. In our study, the IPSS and IPSS-related QOL were significantly improved over the baseline score not only for the LRP and ORP but also for the RARP. For the patients with moderate to severe LUTS preoperatively, the RARP group very immediately improved in terms of preoperative LUTS differently from the LRP and ORP groups. Only RARP significantly improved in terms of VSC differently from both the LRP and ORP procedures. However, none of the procedures changed in the SSC longitudinally. These results suggest that the improvement of LUTS in RARP may contribute to the improvement of not only SSC but also VSC.
It was reported that a substantial proportion of patients were affected by detrusor overactivity, impaired detrusor contractility, decreased compliance, and sphincter weakness in the patients with RP. It has been suggested that bladder denervation during RP may be recognized as one of the reasons for these abnormalities. Wide anatomical dissection around the prostate and bladder neck during RP may cause disruption of regional afferent and efferent innervation, and this finding induces outlet incompetence and partial denervation of the detrusor muscle. This degree of invasiveness and denervation around the bladder neck, which affects voiding function and LUTS, may differ from that associated with each procedure of RP. Our study is the first to longitudinally evaluate the impact of various RP techniques on LUTS and QOL for postoperative 1 year in patients with localized PCa.
Consistent with this concept, it was observed, via sequential urodynamic studies, that there were reductions in maximum cystometric capacity, maximum urethral closure pressure, and maximum detrusor pressure at postoperative 3 months. This postoperative reduction in overall bladder function gradually improved after 3 months but did not reach the baseline level even after 3 years. It was more interesting that the storage symptoms progressively worsened, while voiding symptoms improved in the study.
Although our study was small and lacked data on uroflowmetry and urodynamic variables, it provides important findings on the impact of RP on LUTS. Urodynamic examination would help identify underlying organic changes to the bladder and sphincters for chronic LUTS, but this examination was not practical because of the invasiveness. The other limitation is that it is an observational study with retrospective analysis of the prospectively collected data. The strength of the study includes the length of longitudinal follow-up and inclusion of a urinary QOL instrument.
| Conclusions|| |
There are no studies that have reviewed postoperative outcomes in men with LUTS compared with various procedures of RP. We compare longitudinally the short-time LUTS change of three techniques: RARP, LRP, and ORP. After RARP, the patients with LUTS significantly improved in a statistically significant manner over a 1-year period over the baseline score differently from both LRP and ORP. In particular, patients who underwent RARP significantly improved in terms of VSC, which may improve LUTS. We need to recognize how the RP procedure has an impact on the improvement of LUTS.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Center MM, Jemal A, Lortet-Tieulent J, Ward E, Ferlay J, Brawley O, et al.
International variation in prostate cancer incidence and mortality rates. Eur Urol 2012;61:1079-92.
Steiner MS. Current results and patient selection for nerve-sparing radical retropubic prostatectomy. Semin Urol Oncol 1995;13:204-14.
Walsh PC. Nerve sparing radical prostatectomy for early stage prostate cancer. Semin Oncol 1988;15:351-8.
Berryhill R Jr., Jhaveri J, Yadav R, Leung R, Rao S, El-Hakim A, et al.
Robotic prostatectomy: A review of outcomes compared with laparoscopic and open approaches. Urology 2008;72:15-23.
Ramanathan R, Salamanca JI, Mandhani A, Leung RA, Rao SR, Berryhill R, et al.
Does 3-dimensional (3-D) visualization improve the quality of assistance during robotic radical prostatectomy? World J Urol 2009;27:95-9.
Litwin MS, Hays RD, Fink A, Ganz PA, Leake B, Leach GE, et al.
Quality-of-life outcomes in men treated for localized prostate cancer. JAMA 1995;273:129-35.
Schwartz EJ, Lepor H. Radical retropubic prostatectomy reduces symptom scores and improves quality of life in men with moderate and severe lower urinary tract symptoms. J Urol 1999;161:1185-8.
Hollenbeck BK, Lipp ER, Hayward RA, Montie JE, Schottenfeld D, Wei JT, et al.
Concurrent assessment of obstructive/irritative urinary symptoms and incontinence after radical prostatectomy. Urology 2002;59:389-93.
Steineck G, Helgesen F, Adolfsson J, Dickman PW, Johansson JE, Norlén BJ, et al.
Quality of life after radical prostatectomy or watchful waiting. N Engl J Med 2002;347:790-6.
Masters JG, Rice ML. Improvement in urinary symptoms after radical prostatectomy: A prospective evaluation of flow rates and symptom scores. BJU Int 2003;91:795-7.
Lepor H, Kaci L. The impact of open radical retropubic prostatectomy on continence and lower urinary tract symptoms: A prospective assessment using validated self-administered outcome instruments. J Urol 2004;171:1216-9.
Slova D, Lepor H. The short-term and long-term effects of radical prostatectomy on lower urinary tract symptoms. J Urol 2007;178:2397-400.
Giannantoni A, Mearini E, Zucchi A, Costantini E, Mearini L, Bini V, et al.
Bladder and urethral sphincter function after radical retropubic prostatectomy: A prospective long-term study. Eur Urol 2008;54:657-64.
Barry MJ, Fowler FJ Jr., O'Leary MP, Bruskewitz RC, Holtgrewe HL, Mebust WK, et al.
The American Urological Association symptom index for benign prostatic hyperplasia. The measurement committee of the American Urological Association. J Urol 1992;148:1549-57.
Barry MJ, Fowler FJ Jr., O'Leary MP, Bruskewitz RC, Holtgrewe HL, Mebust WK. Measuring disease-specific health status in men with benign prostatic hyperplasia. Measurement committee of the American Urological Association. Med Care 1995;33:AS145-55.
Matsubara A, Yasumoto H, Mutaguchi K, Mita K, Teishima J, Seki M, et al.
Impact of radical perineal prostatectomy on urinary continence and quality of life: A longitudinal study of Japanese patients. Int J Urol 2005;12:953-8.
Kim JH, Ha YS, Jeong SJ, Lee DH, Kim WJ, Kim IY. Impact of robot-assisted radical prostatectomy on lower urinary tract symptoms and predictive factors for symptom changes: A longitudinal study. Urology 2013;81:787-93.
Prabhu V, Taksler GB, Sivarajan G, Laze J, Makarov DV, Lepor H. Radical prostatectomy improves and prevents age dependent progression of lower urinary tract symptoms. J Urol 2014;191:412-7.
Namiki S, Saito S, Ishidoya S, Tochigi T, Ioritani N, Yoshimura K, et al.
Adverse effect of radical prostatectomy on nocturia and voiding frequency symptoms. Urology 2005;66:147-51.
Matsubara A, Yoneda T, Yasumoto H, Teishima J, Shiina H, Igawa M, et al.
Lower urinary tract symptoms after radical perineal prostatectomy. Jpn J Clin Oncol 2007;37:534-9.
Giannantoni A, Mearini E, Di Stasi SM, Mearini L, Bini V, Pizzirusso G, et al.
Assessment of bladder and urethral sphincter function before and after radical retropubic prostatectomy. J Urol 2004;171:1563-6.
de Nunzio C, Franco G, Rocchegiani A, Iori F, Leonardo C, Laurenti C. The evolution of detrusor overactivity after watchful waiting, medical therapy and surgery in patients with bladder outlet obstruction. J Urol 2003;169:535-9.
Wang L, Chung SF, Yip SK, Lau WK, Cheng CW, Sim HG. The natural history of voiding function after robot-assisted laparoscopic radical prostatectomy. Urol Oncol 2011;29:177-82.
Ohashi T, Yorozu A, Toya K, Saito S, Momma T. Serial changes of international prostate symptom score following I-125 prostate brachytherapy. Int J Clin Oncol 2006;11:320-5.
Song C, Lee J, Hong JH, Choo MS, Kim CS, Ahn H. Urodynamic interpretation of changing bladder function and voiding pattern after radical prostatectomy: A long-term follow-up. BJU Int 2010;106:681-6.
[Figure 1], [Figure 2], [Figure 3], [Figure 4]
[Table 1], [Table 2]