• Users Online: 238
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2019  |  Volume : 30  |  Issue : 5  |  Page : 220-225

The role of c-myc and adiponectin receptors in prostate cancer metastases


1 Department of Urology, Hasan Sadikin Hospital, Universitas Padjadjaran, Bandung, West Java, Indonesia
2 Department of Urology, Cipto Mangunkusumo, University of Indonesia, Bandung, West Java, Indonesia
3 Department of Pathology, Hasan Sadikin Hospital, Universitas Padjadjaran, Bandung, West Java, Indonesia

Correspondence Address:
Ferry Safriadi
Jl. Adipati Kertabumi No 5, Bandung 40115, West Java
Indonesia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/UROS.UROS_153_18

Get Permissions

Purpose: This study aims to analyze the relationship between c-myc and adiponectin receptor expressions to prostate cancer staging and prove the role of c-myc and adiponectin receptors as risk factors of metastatic prostate cancer. Materials and Methods: This was a comparative study. The study sample consisted of 35 cases of metastatic prostate cancer and 35 cases of organ-confined prostate cancer. c-myc and adiponectin receptor expressions were examined by using immunohistochemistry and histoscore assessment with the cutoff point of 4. Chi-square and Mann–Whitney U-test were used to assess differences in c-myc and adiponectin receptor expressions. Stratification test and multiple logistic regressions were used to assess the correlation between the variables. Results: There were significant differences of c-myc expression (P = 0.000; odds ratio [OR]: 67.16 [95% confidence interval (CI): 3.820–180.50]) and adiponectin receptor expression (P = 0.001; OR: 6.0 [95% CI: 2.1–17.5]) between the two groups. The stratification test revealed that when c-myc and adiponectin receptor expressions were positive, the OR was 7.50 (95% CI: 1.827–30.783). Conclusion: c-myc and adiponectin receptors play an essential role in prostate cancer metastases. Positivity of both parameters will increase the probability of metastases.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed113    
    Printed2    
    Emailed0    
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal