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Year : 2019  |  Volume : 30  |  Issue : 4  |  Page : 144-150

Metabolic profiling based on nuclear magnetic resonance spectroscopy and mass spectrometry as a tool for clinical application

1 Associate Professor; UROGIV Research Group, Universidad del Valle, Cali, Colombia
2 Associate Professor; LABIOMOL Research Group, Universidad del Valle, Cali, Colombia

Correspondence Address:
Herney Andrés Garcia-Perdomo
Cll 4B # 36-00, Universidad del Valle, Cali
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/UROS.UROS_2_19

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Metabolomics provides an abundance of information with the potential to accurately describe the physiological state of an organism. It aims to identify small molecules under physiological conditions that might serve as biomarkers and aid in the identification and treatment of health problems. Combining nuclear magnetic resonance (NMR) with mass spectrometry (MS) yields better identification and quantification of compounds, especially in mixtures, as well as the ability to cross-analyze data from both techniques and thereby increase the number of compounds identified. Metabolomic profiling using NMR and/or MS provides an important diagnostic tool for identifying metabolites under different conditions. This also requires a valid and reliable way to standardize the way we use it to identify biomarkers. Regarding the clinical application of metabolomics, for bladder cancer, threonine, phenylalanine, valine, isoleucine, lysine, methionine, leucine, glutamate, histidine, arginine, aspartic acid, tyrosine, glutamine, and serine were found discriminative in diagnosing this entity. On the other side, sarcosine, choline, phosphocholines, phosphorylcholines, carnitines, citrate, amino acids (lysine, glutamine, and ornithine), arachidonoyl amine, and lysophospholipids were found discriminative regarding the prostate cancer diagnosis.

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