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ORIGINAL ARTICLE
Year : 2018  |  Volume : 29  |  Issue : 2  |  Page : 73-80

Surgical menopause exacerbated high-fat and high-sugar diet-induced overactive bladder in a rat model


1 Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
2 Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital; Department of Urology, Kaohsiung Medical University Hospital; Department of Urology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
3 Translational Research Center, Cancer Center, Department of Medical Research, Kaohsiung Medical University, Kaohsiung, Taiwan
4 Graduate Institute of Medical Science, Kaohsiung Medical University, Kaohsiung; Department of Urology, Sinying Hospital, Ministry of Health and Welfare, Tainan, Taiwan
5 Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
6 Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital; Department of Urology, Kaohsiung Medical University Hospital; Department of Urology, College of Medicine, Kaohsiung Medical University; Graduate Institute of Medical Science, Kaohsiung Medical University; Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan

Correspondence Address:
Yung-Shun Juan
Department of Urology, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road Sanmin District, Kaohsiung 807
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/UROS.UROS_8_17

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Objective: The pathophysiology mechanism of menopause in the metabolic syndrome-associated bladder dysfunction is still not clear. The major aims of the present study were to examine the impact of high-fat-high-sugar diet and surgical menopause-induced metabolic syndrome in overactive bladder (OAB). Methods: Female Sprague Dawley rats were feed with high-fat-high-sugar diet with/without ovariectomy surgery to mimic menopause and to induce metabolic syndrome. At 6 months after high-fat-high-sugar feeding, cystometrogram, physical indicator, and urine and serum biochemistry parameters were measured. Masson's trichrome stain and Western blots were carried out to examine the expressions of interstitial fibrosis, fibrosis-associated proteins, and muscarinic or purinergic receptors. Results: Bladder hyperactivity was induced accompanied by bladder interstitial fibrosis after 6 months of high-fat-high-sugar feeding, while surgical menopause exacerbated these bladder damages and enhanced interstitial fibrosis level. In addition, surgical menopause enhanced bladder dysfunction via overexpression of muscarinic and purinergic receptors. Conclusions: High-fat-high-sugar feeding induced bladder overactivity, while ovary hormone deficiency enhanced bladder interstitial fibrosis, exacerbated OAB syndrome, and increased muscarinic and purinergic receptors expressions.


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